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CAS No.: 74711-43-6

扎托布洛芬 Catalog No. CSN17117

Synonyms: CN100;Soleton;CN-100

Zaltoprofen is an inhibitor of COX with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively, can be used for treatment of arthritis.

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生物活性

描述Zaltoprofen, a preferential COX-2 inhibitor, exhibited a potent inhibitory action on the nociceptive responses induced by a retrograde infusion of bradykinin into the right common carotid artery in rats. Zaltoprofen produces an analgesic action on bradykinin-induced nociceptive responses by blocking the B(2) receptor-mediated pathway in the primary sensory neurons^[3]. In comparison to the control group (vehicle), zaltoprofen showed a significant increase in reaction time at various time periods in the hot plate and tail flick tests. In the hot plate method, zaltoprofen groups (15 and 20 mg/kg) showed a significant elevation in pain threshold in comparison to control group (vehicle). In the tail flick model also, zaltoprofen groups (15 and 20 mg/kg) showed a significant increase in the reaction time in comparison to control group (vehicle)^[4]. Moreover, zaltoprofen possesses the ability to activate peroxisome proliferator-activated receptor gamma (PPARγ), can inhibit the proliferation of TGCT (tenosynovial giant cell tumor) stromal cells via PPARγ. PPARγ is a ligand-activated transcription factor that belongs to the nuclear hormone receptor superfamily. It plays an important role in the differentiation of adipocytes from precursor cells and exhibits antitumorigenic effects on certain malignancies^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01205958	Chronic Neck Pain	Not Applicable	Unknown	February 2011	Korea, Republic of ... more >> Kyunghee University East West Neo Medical Center Recruiting Seoul, Korea, Republic of, 134-727 Contact: JaeHeung Cho, OMD +82-2-440-7581 vetkong95@hanmail.net Collapse <<
NCT03013959	-	-	Recruiting	September 2018	China, Beijing ... more >> Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Recruiting Beijing, Beijing, China, 100000 Contact: Yang Jiang, md +8613521676533 jiangyangpumch@126.com Collapse <<
NCT03712670	Retinal Disease	Not Applicable	Completed	-	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.3517 mL
- 16.7585 mL
- 33.5170 mL
- 5 mM
- 0.6703 mL
- 3.3517 mL
- 6.7034 mL
- 10 mM
- 0.3352 mL
- 1.6758 mL
- 3.3517 mL

技术信息

CAS号

74711-43-6

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H14O3S

运输

蓝冰

分子量

298.36

别名

CN100;Soleton;CN-100

溶解度

DMSO	59.0 mg/mL (197.8 mM)
Water	Insoluble
Ethanol	30.0 mg/mL (100.6 mM)

动物实验配方

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